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通过反复吸入结晶二氧化硅粉尘建立的矽肺小鼠模型
 
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通过反复吸入结晶二氧化硅粉尘建立的矽肺小鼠模型

Article DOI: 10.3791/64862-v • 10:45 min • January 6th, 2023
January 6th, 2023 •
*1,2,3,4, *1,2,3,4, 1,3,4, 1,4, 1,4, 1,4, 1,2,3,4, 1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
* These authors contributed equally

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该方案描述了一种通过鼻滴反复暴露于二氧化硅悬浮液来建立矽肺小鼠模型的方法。该模型可以高效、方便、灵活地模拟人体矽肺病的病理过程，重复性和经济性高。

Tags

医学，第191期，小鼠模型，吸入，病理生理学，筛选，治疗，临床症状，急性/慢性转化过程，程序，CSD粉末，盐水混悬液，超声波水浴，麻醉，抽吸，鼻孔吸入，小鼠笼
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