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Evaluating Quantitative Tumor Cell Killing by CAR-Expressing Jurkat Cells

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Hurtig in vitro cytotoksicitetsevaluering af jurkat, der udtrykker kimær antigenreceptor ved hjælp af fluorescerende billeddannelse

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Rapid In Vitro Cytotoxicity Evaluation of Jurkat Expressing Chimeric Antigen Receptor using Fluorescent Imaging

Hurtig in vitro cytotoksicitetsevaluering af jurkat, der udtrykker kimær antigenreceptor ved hjælp af fluorescerende billeddannelse

Evaluating Quantitative Tumor Cell Killing by CAR-Expressing Jurkat Cells

DOI:

10.3791/65560-v

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01:44 min

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October 27, 2023

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Siddharth Subham*^1,2,3, John D. Jeppson*¹, Benjamin K. Gibbs, Jacqueline Babai, Riza Alker, Andrew K. Godwin^5,6, David Akhavan^2,3

¹Department of Radiation Oncology,University of Kansas Cancer Center, ²Department of Cancer Biology,University of Kansas Cancer Center, ³BioEngineering Program,University of Kansas, ⁴Department of Pathology and Laboratory Medicine,University of Kansas Medical Center, ⁵University of Kansas Cancer Center, ⁶Kansas Institute for Precision Medicine,University of Kansas Medical Center

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Keywords: CAR T-cells Jurkat Cells Cytotoxicity Fluorescent Imaging High-throughput Screening CAR Construct Optimization Cancer Immunotherapy

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