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In Situ Mouse Liver Perfusion Model to Study Metabolic Responses to Substrates

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使用灌注小鼠肝脏模型量化肝葡萄糖生成、尿素生成和脂肪分解

JoVE Journal
Medicina

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JoVE Journal Medicina

Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model

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使用灌注小鼠肝脏模型量化肝葡萄糖生成、尿素生成和脂肪分解

In Situ Mouse Liver Perfusion Model to Study Metabolic Responses to Substrates

DOI:

10.3791/65596-v

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01:53 min

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October 06, 2023

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Marie Winther-Sørensen^2,3, Ida Marie Kemp³, Hanne Cathrine Bisgaard, Jens Juul Holst⁵, Nicolai J. Wewer Albrechtsen³

¹Department of Biomedical Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, ²NNF Center for Protein Research, Faculty of Health and Medical Sciences,University of Copenhagen, ³Department for Clinical Biochemistry,Copenhagen University Hospital – Bispebjerg and Frederiksberg, ⁴Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences,University of Copenhagen, ⁵NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences,University of Copenhagen

Tags

Hepatic Glucose Production Ureagenesis Lipolysis Perfused Mouse Liver Model Liver Metabolism Liver Disease Glucagon Signaling Nutrient Metabolism Liver Biology Liver Perfusion

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