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Evaluating Murine BBB Disruption Induced by Hypoxic Human Placenta-Derived sEVs

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Forstyrrelse af musens blod-hjerne-barriere af små ekstracellulære vesikler fra hypoxiske humane moderkager

JoVE Journal
Medicina
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JoVE Journal Medicina

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Forstyrrelse af musens blod-hjerne-barriere af små ekstracellulære vesikler fra hypoxiske humane moderkager

Evaluating Murine BBB Disruption Induced by Hypoxic Human Placenta-Derived sEVs

DOI:

10.3791/65867-v

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01:21 min

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January 26, 2024

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Hermes Sandoval*¹, José León*^1,2, Felipe Troncoso, Valeria de la Hoz, Aaron Cisterna⁴, Moisés Contreras, Fidel O. Castro, Belén Ibañez, Jesenia Acurio, Carlos Escudero⁶

¹Vascular Physiology Laboratory, Department of Basic Sciences,Universidad del Bío-Bío, Chillan, ²Nursery School, Health Faculty,Universidad Santo Tomás, Los Angeles, ³Obstetrics and Gynecology Department,Herminda Martin Clinical Hospital, Chillan, ⁴Faculty of Medicine,Universidad Católica de la Santísima Concepción, Concepcion, ⁵Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences,Universidad de Concepción, Chillan, ⁶Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillan

Tags

Extracellular Vesicles Blood-brain Barrier Placenta Preeclampsia Hypoxia Cerebrovascular Complications Maternal Mortality Brain Endothelial Dysfunction

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