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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

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신경 질환을 모델링하고 치료적으로 표적화하기 위한 체외 혈액-뇌 장벽 재건

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

Please note that all translations are automatically generated. Click here for the English version.

신경 질환을 모델링하고 치료적으로 표적화하기 위한 체외 혈액-뇌 장벽 재건

A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

DOI:

10.3791/65921-v

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02:09 min

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October 20, 2023

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Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^2,3,4,5, Emily Ruth Sartori^2,3,4,5, Rikki B. Rooklin^2,3,4,5, Braxton R. Schuldt^2,3,4,5, Louise A. Mesentier-Louro^2,3,4,5, Joel W. Blanchard^2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

Tags

Blood-brain Barrier In Vitro Model Alzheimer’s Disease Neurodegeneration Cerebrovascular Pathology APOE4 Amyloid Induced Pluripotent Stem Cells Personalized Therapy Drug Screening 3D Model BBB Function Cerebral Amyloid Angiopathy

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