Chapter 5
Acids and Bases
![Brønsted-Lowry Acids and Bases](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11733.jpg)
In 1923, the Brønsted–Lowry definition of acids and bases was proposed by Johannes Brønsted and Thomas Lowry. According to this…
![Lewis Acids and Bases](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11734.jpg)
This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed,…
![Position of Equilibrium in Acid-Base Reactions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11736.jpg)
In any solution, the value of pKa indicates whether an acid is completely dissociated or not. A negative pKa corresponds to a stronger acid, whereas…
![Molecular Structure and Acidity](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11737.jpg)
An acid can be deprotonated to form a conjugate base or an anion. If the produced anion is more stable, then the acid is stronger. On the contrary,…
![Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)](https://cloudfront.jove.com/files/thumbs/51504_t.png)
The direct functionalization of C-H bonds is an important and long standing goal in organic chemistry. Such transformations can be very powerful in…
![Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy](https://cloudfront.jove.com/files/thumbs/60745_t.png)
Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
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Lewis acid-activation of carbonyl-containing substrates is a fundamental basis for facilitating transformations in organic chemistry. Historically,…
![Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly](https://cloudfront.jove.com/files/thumbs/60442_t.png)
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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This protocol presents the use of Lewis acidic multi-role reagents to circumvent kinetic trapping observed during the self-assembly of…