Chapter 37
Cell Death
![Overview of Cell Death](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12425.jpg)
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance…
![Apoptosis](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12426.jpg)
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively.…
![The Extrinsic Apoptotic Pathway](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12428.jpg)
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors…
![The Intrinsic Apoptotic Pathway](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12429.jpg)
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the…
![Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells](https://cloudfront.jove.com/files/thumbs/4254_t.png)
Programmed cell death (PCD) occurs in adults to maintain normal tissue homeostasis and during embryological development to shape tissues and…
![Phagocytosis Assay for Apoptotic Cells in <em>Drosophila</em> Embryos](https://cloudfront.jove.com/files/thumbs/56352_t.png)
The molecular mechanisms underlying the phagocytosis of apoptotic cells need to be elucidated in more detail because of its role in immune and…