Traumatic injury to the spinal cord disrupts communication with the brain. To restore lost connectivity we utilize a peripheral nerve graft to provide a substratum for regenerating fibers in combination with neurotrophic factors and matrix-modulating enzymes to remove inhibitory molecules to promote long distance growth.
This work was supported by NIH/NINDS Grants NS26380 and NS55976, the Christopher and Dana Reeve Foundation and the Daniel Heumann Fund for Spinal Cord Research. The Drexel University College of Medicine Spinal Cord Research Center provides support for core facilities used to complete this work.
Material Name | Type | Company | Catalogue Number | Comment |
---|---|---|---|---|
10-0 silk suture | ArosSurgical | T5A10N10 | ||
6-0 silk suture | McKesson | 2693 | ||
Ampicillin | McKesson | 483549 | ||
Antibody to cFos | Sigma-Aldrich | F7799 | ||
Biotinylated dextran Amine | Invitrogen | D7135 | ||
Buprenorphin (.3mg/ml) | McKesson | 12496075701 | ||
Chondroitinase ABC | Associates of Cape Cod | 100332-1A | ||
Euthasol | Webster Veterinary | 07-805-9296 | ||
Hanks Balanced Salt Solution | Cellgro | 21-021-CV | ||
Isoflurane | Henry Schein | 209-1966 | ||
Michel Wound Clips | Fine Science Tools | 12040-02 | ||
Neurotrace Kit | Invitrogen | N7167 | ||
True Blue | Sigma-Aldrich | T5891 | ||
Xenodine | Webster Veterinary | 92201 | ||
Hot Bead Sterilizer | Fine Science Tools | |||
Forced Exercise Wheel | Lafayette Instruments | |||
TreadScan System | Clever System | |||
Infinite Horizon Impact Device | Precision Systems and Instrumentation | |||
Magnetic Stimulation Device | MagStim Inc. |