Guld Nanostar Syntese med en Silver Seed medierede væksthæmning Metode
Summary
Vi syntetiseret stjerne formet guld nanostars bruge en sølv frø medieret vækst metode. Diameteren på nanostars spænder fra 200 til 300 nm, og antallet af tips varierer fra 7 til 10. Nanopartiklerne har en bred flade plasmon resonans-tilstand centreret i det nærinfrarøde.
Abstract
De fysiske, kemiske og optiske egenskaber af nano-skala kolloider er afhængige af deres materielle sammensætning, størrelse og form 1-5. Der er stor interesse for at bruge nano-kolloider til foto-termisk ablation, drug delivery og mange andre biomedicinske anvendelser 6. Guld er især brugt på grund af den lave giftighed 7-9. En egenskab af metal nano-kolloider er, at de kan have en stærk overflade plasmon resonans 10. Toppen af overfladen plasmon resonans-tilstand afhænger af strukturen og sammensætningen af metal nano-kolloider. Siden overfladen plasmon resonans-tilstand bliver stimuleret med lys der er behov for at have den højeste absorbans i det nærinfrarøde hvor biologisk væv transmissionsevne er maksimal 11, 12.
Vi præsenterer en metode til at syntetisere stjerne formet kolloidt guld, også kendt som stjerne formede nanopartikler 13-15 eller nanostars 16. Denne metode er baseret på såolution indeholdende sølv frø, der bruges som kernedannende agent for anisotropisk vækst af guld kolloider 17-22. Scanning elektron mikroskopi (SEM) analyse af de resulterende guld kolloid viste, at 70% af nanostrukturer var nanostars. De andre 30% af partiklerne var amorfe klynger af decahedra og rhomboids. Absorbansen højdepunktet af nanostars blev konstateret at være i nær infrarød (840 nm). Således er vores metode producerer guld nanostars egnet til biomedicinske applikationer, bl.a. til foto-termisk ablation.
Protocol
Discussion
I dette arbejde har vi præsenteret en metode til at syntetisere guld nanostars med sølv frø. Vi fandt, at sølv frø resulterede i et afkast på 70% produktion af nanostars. De nanostars har en nær infrarød absorption peak, der svarer til deres overflade plasmon resonans-tilstand, centreret mellem 800 nm og 850 nm 7, 23. Disse egenskaber egenskaber tillader vores guld nanostars at være til nytte for biomedicinske anvendelser 24-26, såsom foto-termisk ablation.
En…
Disclosures
The authors have nothing to disclose.
Acknowledgements
Denne forskning blev støttet af National Science Foundation i partnerskaber for forskning og uddannelse i Materialer (PREM) Grant Nej DMR-0934218. Det blev også støttet af Award Antal 2G12RR013646-11 fra National Center for Research Resources. Indholdet er alene forfatternes ansvar og ikke nødvendigvis repræsenterer den officielle synspunkter National Center for Research Resources, eller National Institutes of Health.
Materials
| Name of the reagent | Company | Catalogue number | Purity |
| Sodium citrate tribasic dehydrate | Sigma | S4641 | 99.0 % |
| Silver nitrate | Aldrich | 204390 | 99.9999 % |
| Sodium borohydride | Aldrich | 213462 | 99 % |
| L-Ascorbic acid | Sigma-Aldrich | 255564 | 99+ % |
| Gold chloride trihydrate | Aldrich | 520918 | 99.9+ % |
| Hexadecyltrimethylammonium bromide (CTAB) | Sigma | H6269 |
| Name of equipment | Company | Comments |
| JEOL 2010-F | JEOL | Transmission electron microscope |
| Hitachi S-5500 | Hitachi | Used in scanning electron microscope mode |
| Olis Cary-14 spectrophotometer | Olis | Spectrophotometer |
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