क्रोनिक स्पाइनल कॉर्ड चोट के साथ व्यक्तियों में श्वसन मोटर नियंत्रण आकलन (RMCA) का उपयोग श्वसन मांसपेशी सक्रियण का मूल्यांकन
Summary
इस प्रकाशन का उद्देश्य मात्रात्मक वेक्टर आधारित विश्लेषण का उपयोग कर पुरानी रीढ़ की हड्डी में चोट के साथ लोगों में सांस की मांसपेशी सक्रियण पैटर्न को चिह्नित करने के लिए एक बहु – मांसपेशी सतह electromyographic दृष्टिकोण पर अपने मूल काम को पेश करने की है.
Abstract
During breathing, activation of respiratory muscles is coordinated by integrated input from the brain, brainstem, and spinal cord. When this coordination is disrupted by spinal cord injury (SCI), control of respiratory muscles innervated below the injury level is compromised1,2 leading to respiratory muscle dysfunction and pulmonary complications. These conditions are among the leading causes of death in patients with SCI3. Standard pulmonary function tests that assess respiratory motor function include spirometrical and maximum airway pressure outcomes: Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), Maximal Inspiratory Pressure (PImax) and Maximal Expiratory Pressure (PEmax)4,5. These values provide indirect measurements of respiratory muscle performance6. In clinical practice and research, a surface electromyography (sEMG) recorded from respiratory muscles can be used to assess respiratory motor function and help to diagnose neuromuscular pathology. However, variability in the sEMG amplitude inhibits efforts to develop objective and direct measures of respiratory motor function6. Based on a multi-muscle sEMG approach to characterize motor control of limb muscles7, known as the voluntary response index (VRI)8, we developed an analytical tool to characterize respiratory motor control directly from sEMG data recorded from multiple respiratory muscles during the voluntary respiratory tasks. We have termed this the Respiratory Motor Control Assessment (RMCA)9. This vector analysis method quantifies the amount and distribution of activity across muscles and presents it in the form of an index that relates the degree to which sEMG output within a test-subject resembles that from a group of healthy (non-injured) controls. The resulting index value has been shown to have high face validity, sensitivity and specificity9-11. We showed previously9 that the RMCA outcomes significantly correlate with levels of SCI and pulmonary function measures. We are presenting here the method to quantitatively compare post-spinal cord injury respiratory multi-muscle activation patterns to those of healthy individuals.
Protocol
Representative Results
Discussion
एससीआई और अन्य बीमारियों के बाद सांस की मोटर समारोह का मूल्यांकन करने के लिए मानक नैदानिक परीक्षण फेफड़े समारोह परीक्षण और अमेरिकी रीढ़ की हड्डी में चोट एसोसिएशन हानि स्केल (एआईएस) मूल्यांकन 14,15…
Disclosures
The authors have nothing to disclose.
Acknowledgements
, क्रेग एच. Neilsen फाउंडेशन (अनुदान 1000056824 – HN000PCG) और राष्ट्रीय – यह काम क्रिस्टोफर और दाना रीव फाउंडेशन (अनुदान CDRF OA2-0802-2), केंटकी रीढ़ की हड्डी और सिर में चोट रिसर्च ट्रस्ट (KSCHIRT अनुदान 9-10A) द्वारा समर्थित किया गया स्वास्थ्य संस्थान: राष्ट्रीय हृदय फेफड़े और रक्त संस्थान (अनुदान 1R01HL103750-01A1).
Materials
| Name of the Device | Vendor | Product # | Comments |
| PowerLab System 16/35 | ADInstruments | PL3516 | Number of units depends on number of channels recorded |
| EMG System MA 300 | Motion Lab Systems | MA300-XVI | Number of units depends on number of channels recorded |
| Low Pressure Transducer MP45 | Validyne | MP45-40-871 | |
| Basic Carrier Demodulator CD15 | Validyne | CD15-A-2-A-1 | |
| Air Pressure Manometer | Boehringer | 4103 | Needed for MP45 calibration |
| Event Marker | Hand held switch that when pressed gives a DC voltage and sound output (including 5-sec long mark) | ||
| Alcohol Wipes | Henry Schein | 1173771 | Needed for electrodes placement |
| Electrode Gel | Lectron II | 36-3000-25 | Needed for electrodes placement |
| Tagaderm | Henry Schein | 7779152 | Needed for electrodes placement |
| Noseclip | Henry Schein | 1089460 | |
| T-piece Ventilator Monitoring Circuit with One-way Valves | Alleglance (Airlife) | 1504 | |
| Air Tube | UnoMedical | 400E | |
| Table 1. List of specific equipment and supplies used for the Respiratory Motor Control Assessment. |
References
- Schilero, G. J., Spungen, A. M., Bauman, W. A., Radulovic, M., Lesser, M. Pulmonary function and spinal cord injury. Respir. Physiol. Neurobiol. 166, 129-141 (2009).
- Winslow, C., Rozovsky, J. Effect of spinal cord injury on the respiratory system. Am. J. Phys. Med. Rehabil. 82, 803-814 (2003).
- Garshick, E., et al. A prospective assessment of mortality in chronic spinal cord injury. Spinal Cord. 43, 408-416 (2005).
- Jain, N. B., Brown, R., Tun, C. G., Gagnon, D., Garshick, E. Determinants of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC in chronic spinal cord injury. Arch. Phys. Med. Rehabil. 87, 1327-1333 (2006).
- Stolzmann, K. L., Gagnon, D. R., Brown, R., Tun, C. G., Garshick, E. Longitudinal change in FEV1 and FVC in chronic spinal cord injury. Am. J. Respir. Crit. Care Med. 177, 781-786 (2008).
- . American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am. J. Respir. Crit. Care Med. 166, 518-624 (2002).
- Sherwood, A. M., McKay, W. B., Dimitrijevic, M. R. Motor control after spinal cord injury: assessment using surface EMG. Muscle Nerve. 19, 966-979 (1996).
- Lee, D. C., et al. Toward an objective interpretation of surface EMG patterns: a voluntary response index (VRI). J. Electromyogr. Kinesiol. 14, 379-388 (2004).
- Ovechkin, A., Vitaz, T., de Paleville, D. T., Aslan, S., McKay, W. Evaluation of respiratory muscle activation in individuals with chronic spinal cord injury. Respir. Physiol. Neurobiol. 173, 171-178 (2010).
- Lim, H. K., Sherwood, A. M. Reliability of surface electromyographic measurements from subjects with spinal cord injury during voluntary motor tasks. J. Rehabil. Res. Dev. 42, 413-422 (2005).
- Lim, H. K., et al. Neurophysiological assessment of lower-limb voluntary control in incomplete spinal cord injury. Spinal Cord. 43, 283-290 (2005).
- Sherwood, A. M., Graves, D. E., Priebe, M. M. Altered motor control and spasticity after spinal cord injury: subjective and objective. 37, 41-52 (2000).
- McKay, W. B., Lim, H. K., Priebe, M. M., Stokic, D. S., Sherwood, A. M. Clinical neurophysiological assessment of residual motor control in post-spinal cord injury paralysis. Neurorehabil. Neural Repair. 18, 144-153 (2004).
- Marino, R. J., et al. International standards for neurological classification of spinal cord injury. J. Spinal. Cord. Med. 26, S50-S56 (2003).
- American Spinal Injury Association and International Spinal Cord Society. . International Standards for Neurological Classification of Spinal Cord Injury. , (2006).
