कुशल चूहा में पहुँचना Forelimb की संरचना: एक आंदोलन रेटिंग स्केल
Summary
कुशल पहुँचने पैमाने पर समग्र तत्वों प्रत्येक जिनमें से एक तीन सूत्री पैमाने के साथ मूल्यांकन कर रहे हैं में खाद्य कार्य के लिए पहुंच में forelimb द्वारा आंदोलन बिताते हैं. दर्ज़ा पैमाने पर एक सामान्य चूहे के लिए वर्णित है और स्नायविक मोटर विकारों के मूल्यांकन की ओर लागू किया जा सकता है.
Abstract
Skilled reaching for food is an evolutionary ancient act and is displayed by many animal species, including those in the sister clades of rodents and primates. The video describes a test situation that allows filming of repeated acts of reaching for food by the rat that has been mildly food deprived. A rat is trained to reach through a slot in a holding box for food pellet that it grasps and then places in its mouth for eating. Reaching is accomplished in the main by proximally driven movements of the limb but distal limb movements are used for pronating the paw, grasping the food, and releasing the food into the mouth. Each reach is divided into at least 10 movements of the forelimb and the reaching act is facilitated by postural adjustments. Each of the movements is described and examples of the movements are given from a number of viewing perspectives. By rating each movement element on a 3-point scale, the reach can be quantified. A number of studies have demonstrated that the movement elements are altered by motor system damage, including damage to the motor cortex, basal ganglia, brainstem, and spinal cord. The movements are also altered in neurological conditions that can be modeled in the rat, including Parkinson’s disease and Huntington’s disease. Thus, the rating scale is useful for quantifying motor impairments and the effectiveness of neural restoration and rehabilitation. Because the reaching act for the rat is very similar to that displayed by humans and nonhuman primates, the scale can be used for comparative purposes. from a number of viewing perspectives. By rating each movement element on a 3-point scale, the reach can be quantified. A number of studies have demonstrated that the movement elements are altered by motor system damage, including damage to the motor cortex, basal ganglia, brainstem, and spinal cord. The movements are also altered in neurological conditions that can be modeled in the rat, including Parkinson’s disease and Huntington’s disease. Thus, the rating scale is useful for quantifying motor impairments and the effectiveness of neural restoration and rehabilitation.
Experiments on animals were performed in accordance with the guidelines and regulations set forth by the University of Lethbridge Animal Care Committee in accordance with the regulations of the Canadian Council on Animal Care.
Protocol
Discussion
चूहे में अंग उपयोग की पिछले अध्ययनों अंत अंक, सफलता या विफलता के मामले में या लक्ष्य की ओर पंजा का एक काटीज़ियन प्रक्षेपवक्र के मामले में आंदोलन की विशेषता है. वर्तमान अध्ययन अंग क्षेत्रों, शरीर के अन्य भागों औ…
Acknowledgements
अनुसंधान कनाडा के प्राकृतिक विज्ञान और इंजीनियरिंग अनुसंधान परिषद द्वारा समर्थित
References
- Whishaw, I. Q., Pellis, S. M. The structure of skilled forelimb reaching in the rat. Bev. Br. Res. 41, 49-59 (1990).
- Whishaw, I. Q., Kolb, B. . The behavior of the laboratory rat. , 162-170 (2005).
