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淀粉样β-蛋白，阿尔茨海默氏病的病原体适配的选择

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

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淀粉样β-蛋白，阿尔茨海默氏病的病原体适配的选择

DOI:

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15:23 min

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May 13, 2010

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Farid Rahimi, Gal Bitan^2,3

¹Department of Neurology,David Geffen School of Medicine, ²Molecular Biology Institute,University of California, Los Angeles, ³Brain Research Institute,University of California, Los Angeles

Chapters

00:00Title
01:03Introduction
01:32Preparing the Protein
03:24Preparing the RNA Pool
07:58RNA-Protein Incubation and Filter Binding
13:24Representative Results of SELEX for Amyloid -Protein
14:41Conclusion

Summary

Automatic Translation

适配选定的短ribo-/deoxyribo-oligonucleotides<em在体外</em>基于对特定目标的亲和力的进化方法。适配与多才多艺的治疗，诊断和研究中的应用的分子识别工具。我们表现出淀粉样β-蛋白，阿尔茨海默氏病的病原体选择适配方法。

Tags

Aptamers Amyloid Î²-protein Alzheimer’s Disease Neurodegenerative Disorder Presymptomatic Diagnosis Early Diagnosis Effective Therapies AÎ² Assemblies Synaptic Dysfunction Neuron Loss AD Etiology AD Pathogenesis Molecular Recognition Tools Antibodies Aptamers Advantages SELEX (systematic Evolution Of Ligands By Exponential Enrichment)

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