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Journal
/
Biochemistry
/
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
/
Interferometría de biocapas (BLI) para evaluar la formación de complejos ternarios inducidos por PROTACS
JoVE Journal
Biochemistry
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JoVE Journal
Biochemistry
Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation
Please note that all translations are automatically generated.
Click here for the English version.
Interferometría de biocapas (BLI) para evaluar la formación de complejos ternarios inducidos por PROTACS
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
DOI:
10.3791/200655-v
•
01:23 min
•
January 12, 2024
•
Wei Jiang
,
Holly Soutter
1
Center for the Development of Therapeutics
,
The Broad Institute of MIT and Harvard
Tags
Keywords: Biolayer Interferometry
BLI
PROTACS
Ternary Complex Formation
VHL
MZ1
BRD4
Binary Complex
Ternary Complex
On Rate
Off Rate
Equilibrium Dissociation Constant
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