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Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
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Medicine
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JoVE Journal Medicine
Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

DOI:
10.3791/3107-v

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11:24 min

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October 18, 2011

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, , , ,
1Department of Radiation Oncology,University of California Irvine

Chapters

  • 00:05Title
  • 01:43Radiotherapy: Treatment Planning and Irradiation
  • 04:51Surgery and Transplantation
  • 09:50Locating Transplanted Neural Stem Cells
  • 10:26Conclusion

Summary

Automatic Translation

Automatic Translation

Brain tumor patients routinely undergo cranial radiotherapy, and while beneficial, this treatment often results in debilitating cognitive dysfunction. This serious unresolved problem has at present, no clinical recourse, and has driven our efforts to devise stem cell based therapies for the recovery of radiation-induced cognitive decrements.

Tags

Stem Cell TransplantationCognitive DysfunctionCranial RadiotherapyBrain TumorsNeural Stem CellsRadiation-induced Cognitive DeclineAthymic Nude RatsHippocampusHuman Neural Stem Cells (hNSCs)Cognition ImprovementGrafted Cell SurvivalDifferentiation-specific Markers

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