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Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury
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JoVE Journal Medicine
Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury

Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury

DOI:
10.3791/3116-v

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10:25 min

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August 30, 2011

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, , , ,
1Department of Anesthesiology and Perioperative Medicine,Oregon Health & Sciences University, 2Department of Pharmacology,University of Colorado Denver

Chapters

  • 00:05Title
  • 01:32Surgical Preparation
  • 03:47Cardiac Arrest
  • 06:53Perfusion, Fixation and Kidney Harvest
  • 07:19Assessment of Murine Renal Damage after CA/CPR
  • 10:00Conclusion

Summary

Automatic Translation

Automatic Translation

A powerful model for perioperative and critical care related acute kidney injury is presented. Using whole body hypoperfusion induced by cardiac arrest it is possible to nearly replicate the histologic and functional changes of clinical AKI.

Tags

Normothermic Cardiac ArrestCardiopulmonary ResuscitationMouse ModelIschemia-reperfusion InjuryAcute Kidney InjuryCritical IllnessWhole-body HypoperfusionRodent ModelsFocal IschemiaGenetic ManipulationCardiac Arrest And Cardiopulmonary Resuscitation ModelPhysiologic OutcomesFunctional OutcomesAnatomic OutcomesHistologic OutcomesMurine Surgical ModelOrgan-specific Outcomes

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