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Synthesis of an In vivo MRI-detectable Apoptosis Probe
JoVE Journal
Biology
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JoVE Journal Biology
Synthesis of an In vivo MRI-detectable Apoptosis Probe
DOI:

06:58 min

July 31, 2012

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Chapters

  • 00:05Title
  • 01:05Conjugation of Annexin V to SPIO and Dynamic Light Scattering
  • 03:19Cell Culture, Induction of Apoptosis in Culture, and MRI of Cultured Cells
  • 04:16In vitro MRI
  • 05:32Representative MRI Results
  • 06:38Conclusion

Summary

Automatic Translation

Early detection of apoptosis may identify at-risk cell populations in a variety of diseases. Here we demonstrate a method to link an early apoptosis-detection protein (Annexin V) to a MRI-detectable iron oxide nanoparticle (SPIO). This method may be extended to other proteins of interest to generate MRI-detectable molecular imaging probes.

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