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Chapters
- 00:05Title
- 01:12Set-up and Surgical Preparation
- 02:44Surgical Procedures
- 04:41Ischemia Protocol
- 06:41Sample Collection and Analysis
- 07:51Results: Neuronal Changes after Ischemia
- 08:55Conclusion
Bilateral carotid occlusion coupled with systemic hypotension produces global brain ischemia in the rat, resulting in damage to the hippocampus with reproducible severity. Animal subjects are impaired with predictable patterns of brain damage, they recover expediently, and mortality rates are comparatively low.
