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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
 

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Article DOI: 10.3791/50331-v • 11:22 min • April 29th, 2013
April 29th, 2013 •
1, 1, 1, 2, 1
1Department of Neurology, University of Michigan, 2Department of Internal Medicine, University of Michigan

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Summary
Automatic Translation

In order to study the changes of nociceptive intraepidermal nerve fibers (IENFs) in painful neuropathies (PN), we developed protocols that could directly examine three-dimensional morphological changes observed in nociceptive IENFs. Three-dimensional analysis of IENFs has the potential to evaluate the morphological changes of IENF in PN.

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Keywords: 3D Imaging Nociceptive Intraepidermal Nerve Fibers Skin Biopsy Peripheral Polyneuropathy PGP TrkA Confocal Microscopy Neuropathy
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