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Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies
JoVE Journal
Medicine
Author Produced
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JoVE Journal Medicine
Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies
DOI:

08:40 min

June 09, 2013

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Chapters

  • 00:01Title
  • 01:09Introduction
  • 01:54Preparation
  • 02:30Tool presentation
  • 03:12Anesthesia procedure
  • 04:05Surgery for illumination of the targeted area
  • 05:44Rose Bengal injection and activation
  • 06:20Suture
  • 07:06Representative results
  • 07:55Conclusion

Summary

Automatic Translation

Photothrombosis is a quick, minimally-invasive technique for inducing small and well-delimited infarction in areas of interest in highly reproducible manner. It is particularly suitable for studying cellular and molecular responses underlying brain plasticity in transgenic mice.

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