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Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
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Bioengineering
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JoVE Journal Bioengineering
Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

DOI:
10.3791/50387-v

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08:04 min

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April 25, 2013

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, , ,
1Department of Orthopaedics,The Warren Alpert Brown Medical School of Brown University and the Rhode Island Hospital, 2Center for Restorative and Regenerative Medicine,VA Medical Center, Providence, RI, 3University of Texas Southwestern Medical Center

Chapters

  • 00:05Title
  • 01:22Biaxial Loading Bioreactor Design
  • 03:35Immobilization of Samples With Agarose
  • 04:38Mechanical Loading of Tissue Constructs
  • 06:25Results: Mechanical Loading Alters Extracellular Matrix Depositing in Tissue Engineered Cartilage
  • 07:44Conclusion

Summary

Automatic Translation

Automatic Translation

We designed a novel mechanical loading bioreactor that can apply uniaxial or biaxial mechanical strain to a cartilage biocomposite prior to transplantation into an articular cartilage defect.

Tags

Keywords: Biaxial Mechanical LoadingBioreactorCartilage ConstructsUniaxial LoadingBiaxial LoadingStepper Motor ActuatorsClosed-loop Stepper Motor DriverMicro-steppingLinear Optical EncodersNanopositioningPrecision Miniature Load CellForce FeedbackMechanical Testing

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