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大鼠建立压力超负荷心肌肥厚模型在升主动脉缩窄

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Medicine
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JoVE Journal Medicine

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Please note that all translations are automatically generated. Click here for the English version.

大鼠建立压力超负荷心肌肥厚模型在升主动脉缩窄

DOI:

10.3791/50983-v

•

10:18 min

•

June 29, 2014

•

Ajith Kumar GS*¹, Binil Raj*¹, Santhosh Kumar S, Sanjay G, Chandrasekharan Cheranellore Kartha

¹Cardio Vascular Disease Biology,Rajiv Gandhi Centre for Biotechnology, ²Animal Research Facility,Rajiv Gandhi Centre for Biotechnology, ³Cardiology Department,Sree Chitra Tirunal Institute for Medical Sciences & Technology

Chapters

00:00Title
00:06Introduction
02:30Pre-Operative Care and Anesthesia
02:43Preparation of the Surgical Site
03:22Tracheal Intubation in Rat
04:05Constriction of Ascending Aorta
07:05Post-operative Care
07:58Confirmation of Successful Constriction of Ascending Aorta
08:14Representative Results
09:21Conclusion

Summary

Automatic Translation

我们描述了使用一个小的金属夹子由升主动脉缩窄建立压力负荷和左心室肥厚大鼠一个逐步的过程。该模型被广泛用于心肌肥厚过程中学习重塑变化，物色及评估策略，这种变化的回归。

Tags

Ascending Aortic Constriction Pressure Overload Cardiac Hypertrophy Heart Failure Surgical Model Rats Trachea Intubation Aorta Constriction Doppler-echocardiography Cardiac Remodeling Contractile Properties

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