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Journal / Bioengineering / Imaging Denatured Collagen Strands In vivo and Ex …
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Bioengineering

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JoVE Journal Bioengineering
Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
 

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Article DOI: 10.3791/51052-v • 07:03 min • January 31st, 2014
January 31st, 2014 •
1, 2, 2,3, 1,3
1Department of Bioengineering, University of Utah, 2Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 3Institute for NanoBiotechnology, Johns Hopkins University

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Summary
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This procedure demonstrates in vivo near IR fluorescence imaging of collagen remodeling activities in mice as well as ex vivo staining of collagens in tissue sections using caged collagen mimetic peptides that can be photo-triggered to hybridize with denatured collagen strands.

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Keywords: Collagen Denatured Collagen Extracellular Matrix Tissue Remodeling Caged Collagen Mimetic Peptide Photo-triggered Hybridization In Vivo Imaging Ex Vivo Imaging Proteases Triple Helix
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