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乳腺癌的一种新的转基因小鼠模型：转移性乳腺癌通过瞄准导管上皮与腺病毒Cre重组酶的启动
JoVE Journal
Medicine
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JoVE Journal Medicine
Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
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乳腺癌的一种新的转基因小鼠模型：转移性乳腺癌通过瞄准导管上皮与腺病毒Cre重组酶的启动

DOI:
10.3791/51171-v

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07:13 min

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March 26, 2014

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, , , , , , , , , ,
1Tumor Microenvironment and Metastasis Program,Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine,University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics,Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine,University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center,University of Pennsylvania, 6Center for Advanced Medicine,University of Pennsylvania

Chapters

  • 00:05Title
  • 01:13Intraductal Injection of Virus Particles
  • 04:00Results: Representative Tumor Formation and Metastasis
  • 06:35Conclusion

Summary

Automatic Translation

Automatic Translation

活化的潜在的突变腺病毒Cre重组到乳腺导管系统的结果在一个临床相关的转移性乳腺癌。注册一个YFP的启动子可以让远端转移性肿瘤细胞的跟踪。这个模型是研究潜转移，抗肿瘤免疫力，而为设计新颖的免疫疗法治疗乳腺癌有用。

Tags

Metastatic Breast CarcinomaTransgenic Mouse ModelDuctal EpitheliumAdenovirus-creP53 AblationK-ras OncogeneTumor ProgressionLymphovascular InvasionLeukocyte InfiltrationLatent MetastasisDormancyImmunotherapy

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