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Modeling Spontan metastaserende renalcellecarcinom (MRCC) i mus efter nefrektomi
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JoVE Journal Medicine
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontan metastaserende renalcellecarcinom (MRCC) i mus efter nefrektomi

DOI:
10.3791/51485-v

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11:27 min

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April 29, 2014

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, , , ,
1Genitourinary Section, Department of Medicine,Roswell Park Cancer Institute, 2Biological Sciences Platform,Sunnybrook Research Institute

Chapters

  • 00:05Title
  • 02:13Orthotopic Kidney Tumor Implantation
  • 05:37Nephrectomy/Primary Tumor Removal
  • 06:51Monitoring Metastatic Progression and Localization at Endpoint
  • 09:47Results: Assessment of Metastasis Location and Severity
  • 10:19Conclusion

Summary

Automatic Translation

Automatic Translation

Modeller af spontan metastatisk renalcellekarcinom (RCC) sygdomsprogression kan anvendes til at evaluere behandlinger i klinisk relevant indstilling. Denne protokol demonstrerer forskellige procedurer for ortotopisk nyre tumor celle implantation, ordentlig nefrektomi, og endelig skitserer en obduktion vejledning for visuel og selvlysende scoring af metastatisk byrde og lokalisering.

Tags

Keywords: Metastatic Renal Cell CarcinomaMRCCMouse ModelNephrectomyOrthotopic Tumor ImplantationSyngeneic ModelBioluminescent ImagingMetastatic Disease ProgressionTherapeutic Testing

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