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在乳腺癌检测人类白细胞抗原生物标志物的利用无标记生物传感技术
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
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在乳腺癌检测人类白细胞抗原生物标志物的利用无标记生物传感技术

DOI:
10.3791/52159-v

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08:27 min

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March 24, 2015

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, , , , , , , ,
1Experimmune, A Center for Immunotherapeutic Development, Department of Immunotherapeutics and Biotechnology,Texas Tech University Health Sciences Center, 2Resonant Sensors Incorporated, 3University of Texas Arlington

Chapters

  • 00:05Title
  • 02:13Addition of Biotinylated Antibody
  • 04:40Addition of Analyte
  • 07:03Results: FLSL/HLA Complexes are Detected in Patient Plasma Samples
  • 07:50Conclusion

Summary

Automatic Translation

Automatic Translation

完整的I类HLA /肽复合物是由肿瘤细胞脱落，代表了潜在的癌症相关的生物标志物。利用无标记传感器技术和T细胞受体的模仿的单克隆抗体，检测棚-MIF / HLA-A *的02：01配合在MDA-MB-231细胞上清液，掺入人血清，并且患者血浆证明，有利的发展一种新型癌症诊断平​​台。

Tags

Breast CancerHuman Leukocyte Antigen (HLA)T-cell Receptor Mimic (TCRm) Monoclonal AntibodiesMacrophage Migration Inhibitory Factor (MIF)NY-ESO-1Label-free BiosensorGuided-mode Resonance (GMR) SensorCancer BiomarkersPersonalized MedicineCompanion DiagnosticsImmunotherapy

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