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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

DOI:
10.3791/52450-v

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10:28 min

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June 07, 2015

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, , , , , , ,
1Institute for Complex Molecular Systems, Department of Biomedical Engineering, Laboratory of Chemical Biology,Eindhoven University of Technology, 2Department of Cardiology, Division Heart and Lungs, Interuniversity Cardiology Institute of the Netherlands (ICIN),University Medical Center Utrecht

Chapters

  • 00:05Title
  • 02:11Formulation of the Hydrogel
  • 03:10Erosion and Release Experiments
  • 04:18Electromechanical Mapping
  • 06:19Intramyocardial Injection
  • 07:53In Vitro Drug Release
  • 08:28In Vitro Endomyocardial Mapping
  • 09:25Conclusion

Summary

Automatic Translation

Automatic Translation

Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.

Tags

Supramolecular HydrogelInjectable HydrogelCatheter InjectionMyocardial RegenerationDrug DeliveryGrowth FactorsExosomes3D Electromechanical Mapping

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