/

/

正常小鼠β淀粉样肽侧脑室注射敏锐地诱导老年痴呆样认知缺陷

JoVE Journal
Neuroscience

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Neuroscience

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits

Please note that all translations are automatically generated. Click here for the English version.

正常小鼠β淀粉样肽侧脑室注射敏锐地诱导老年痴呆样认知缺陷

DOI:

10.3791/53308-v

•

08:01 min

•

March 16, 2016

•

Hye Yun Kim², Dongkeun K. Lee, Bo-Ryehn Chung³, Hyunjin V. Kim⁴, YoungSoo Kim⁴

¹Center for Neuro-Medicine,Korea Institute of Science and Technology, ²Research Institute,GoshenBiotech, Inc., ³Department of Chemical and Biological Engineering,Princeton University, ⁴Biological Chemistry Program,Korea University of Science and Technology

Chapters

00:05Title
01:30Aβ Peptide and Syringe Preparation
02:54Aβ Injection in Mouse
06:06Results: Confirmation of Prepared Aβ Species via SDS-PAGE and Y-maze Behavioral Tests
07:07Conclusion

Summary

Automatic Translation

淀粉样蛋白β（Aβ）-injected动物模型能够确定的数量和Aβ片段的物种的管理，并降低每个研究组内的个体差异。本协议描述Aβ的脑室（ICV）注射立体定向仪，使生产正常小鼠老年痴呆样行为异常。

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

新生小鼠脑侧脑室注射病毒的持续和广泛的神经元传导

为记录细胞内电压响应电法<em>果蝇</em>光感受器和中间对光刺激<em>在体内</em

粉扑诱导的全细胞电流在脑切片中的应用

小鼠用树脂叶毒素和疼痛测试进行脑血管内治疗

开放式协作学习中的脑间同步：fNIRS超扫描研究

如何在fNIRS超扫描研究中计算和验证脑间同步

使用偏小波变换相干法测量 fNIRS-超扫描数据中的定向信息流

自由移动小鼠中肠道来源的微生物代谢物的脑室内递送

检测高功能卒中患者认知缺陷的双任务斯特鲁普范式

自由移动小鼠的多通道细胞外记录

Read Article