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在头固定小鼠胡须信号眨眼经典条件反射
JoVE Journal
Behavior
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JoVE Journal Behavior
Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
DOI:

10:14 min

March 30, 2016

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Chapters

  • 00:05Title
  • 01:00Preparing the Headpiece
  • 02:50Surgery
  • 07:03Habituating the Mouse to the Cylinder
  • 08:23Results: Conditioned Response to Paired and Unpaired Stimulus
  • 09:24Conclusion

Summary

Automatic Translation

The preparation presented here for whisker-signaled eyeblink conditioning in head-fixed mice precisely stimulates specific whiskers while allowing mice to ambulate on a cylindrical treadmill. A whisker stimulation conditioned stimulus (CS) paired with a periorbital shock unconditioned stimulus (US) results in reliable associative learning on this apparatus.

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