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高含量<em>体外</em>胰岛β细胞复制发现平台

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Medicine

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JoVE Journal Medicine

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Please note that all translations are automatically generated. Click here for the English version.

高含量<em>体外</em>胰岛β细胞复制发现平台

DOI:

10.3791/54298-v

•

09:35 min

•

July 16, 2016

•

Zhengshan Zhao, Yassan Abdolazimi, Neali A. Armstrong, Justin P. Annes

¹Department of Medicine, Division of Endocrinology,Stanford University School of Medicine

Chapters

00:05Title
00:57Pancreas Perfusion
01:54Pancreas Dissociation
03:41Islet Purification
05:55Islet Cell Dispersion and Plating and Culture Treatment
08:06Results: Dipyridamole Treatment Induces Beta- But Not Alpha-cell Replication
08:48Conclusion

Summary

Automatic Translation

对于糖尿病研究领域的关键挑战是要明白，调节胰岛β细胞的复制，并制定刺激β细胞再生方法的分子机制。在此高内涵筛选的方法来识别和评估小分子的β细胞复制促进活性表示。

Tags

Keywords: In Vitro Pancreatic Islet β-cell Replication Screening Platform Beta Cell Biology Regenerative Therapy Diabetes Pancreatic Digestion Collagenase

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