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JoVE Journal Bioengineering
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
 

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Article DOI: 10.3791/54445-v • 09:30 min • October 7th, 2016
October 7th, 2016 •
1, 1, 1
1Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano

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Summary
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We present a protocol for the synthesis of RGD-functionalized hydrogels as devices for cell and drug delivery. The procedure involves copper catalyzed alkyne-azide cycloaddition (CuAAC) between alkyne-modified polyacrylic acid (PAA) and a RGD-azide derivative. The hydrogels are formed using microwave-assisted polycondensation and their physicochemical properties are investigated.

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Keywords: RGD-functionalized Hydrogels Tissue Engineering Cell Viability Three-dimensional Cell Culture Spinal Cord Injury Regenerative Medicine RGD-azide Derivative PAA Alkyne Modification Proton Nuclear Magnetic Resonance Spectroscopy Dialysis
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