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An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment
 

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Article DOI: 10.3791/54619-v 09:33 min September 13th, 2016
September 13th, 2016

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Summary

A low-cost, easy-to-use and powerful system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach induced by histamine. Blood vessel leakage, Müller cell activation and the continuity of neuronal processes are utilized to assess the damage response and its reversal with a potential drug, lipoxin A4.

Tags

Keywords: Blood Retinal Barrier Neural Degenerative Diseases Ex Vivo Retinal Model Drug Screening Tissue Culture Retina Dissection Histamine LXA4 PFA Sucrose Freezing Medium
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