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En omfattande förfarande för att utvärdera<em> In Vivo</em> Prestanda av cancer nano
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
DOI:

07:59 min

March 04, 2017

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Chapters

  • 00:05Title
  • 00:56Synthesis of Dual-labeled Liposomal Nanoparticles
  • 03:22In Vivo PET-CT Imaging and Ex Vivo Biodistribution Measurements
  • 06:19Results: Biodistribution of Fluorescent- and Radiolabeled Nanoparticles in Tumor-bearing Mice
  • 07:14Conclusion

Summary

Automatic Translation

The poor understanding of the in vivo performance of nanomedicines stymies their clinical translation. Procedures to evaluate the in vivo behavior of cancer nanomedicines at systemic, tissue, single-cell, and subcellular levels in tumor-bearing immunocompetent mice are described here. This approach may help researchers to identify promising cancer nanomedicines for clinical translation.

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