A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 00:55Dosator Assembly, Filling and Actuation
- 02:39Results: Representative Pharmacokinetic Evaluation via Passive Inhalation
- 03:38Conclusion
During development of drugs for pulmonary delivery, it is necessary to evaluate pharmacokinetics and efficacy in an animal model. We present a method to build a disposable aerosol dispersion system from of-the-shelf components that can be used to administer intrapulmonary dry powder aerosol to rodents.
Tags
Keywords:
Disposable DosatorPulmonary InsufflationTherapeutic AgentsSmall AnimalsDry Powder AerosolAerosol Dispersion SystemAerosol SciencePharmacokineticsEfficacy TestingPolypropylene Microcentrifuge TubeStainless Steel Wire ClothAnalytical MicrobalanceSyringeDosing PortExposure ChamberAcrylic Dosing Chamber
