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Engangs dosatorerne til pulmonal Insufflation af terapeutiske midler til smådyr
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JoVE Journal Medicine
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Engangs dosatorerne til pulmonal Insufflation af terapeutiske midler til smådyr

DOI:
10.3791/55356-v

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04:22 min

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March 30, 2017

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, , , , ,
1RTI International, 2Oklahoma University Health Science Center, 3University of North Carolina at Chapel Hill

Chapters

  • 00:05Title
  • 00:55Dosator Assembly, Filling and Actuation
  • 02:39Results: Representative Pharmacokinetic Evaluation via Passive Inhalation
  • 03:38Conclusion

Summary

Automatic Translation

Automatic Translation

Under udviklingen af ​​lægemidler til pulmonal levering, er det nødvendigt at vurdere farmakokinetik og effekt i en dyremodel. Vi præsenterer en fremgangsmåde til at bygge en engangs aerosol dispersionssystem fra of-the-shelf komponenter, der kan anvendes til indgivelse af intrapulmonal tørpulveraerosol til gnavere.

Tags

Disposable DosatorPulmonary InsufflationTherapeutic AgentsSmall AnimalsDry Powder AerosolAerosol Dispersion SystemAerosol SciencePharmacokineticsEfficacy TestingPolypropylene Microcentrifuge TubeStainless Steel Wire ClothAnalytical MicrobalanceSyringeDosing PortExposure ChamberAcrylic Dosing Chamber

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