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Pentylenetetrazole-indusert Kindling musemodell
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JoVE Journal Neuroscience
Pentylenetetrazole-Induced Kindling Mouse Model

Pentylenetetrazole-indusert Kindling musemodell

DOI:
10.3791/56573-v

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07:06 min

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June 12, 2018

•

,
1Synaptic Plasticity Project,Tokyo Metropolitan Institute of Medical Science

Chapters

  • 00:04Title
  • 00:38Injection of PTZ
  • 01:20Three Chamber Test
  • 04:18Contextual Fear Discrimination
  • 05:29Results: Repetitive Injection of PTZ Induces an Increase in Seizure Severity
  • 06:26Conclusion

Summary

Automatic Translation

Automatic Translation

Dette beskriver en metode for kjemiske kindling med pentylenetetrazole og gir en musemodell av epilepsi. Denne protokollen kan også brukes til å undersøke å anfall induksjon og patogenesen etter epileptiske anfall i mus.

Tags

Pentylenetetrazole-Induced KindlingMouse ModelEpilepsySeizureHistological ChangesNeuropsychiatric DisordersPTZSodium ChlorideIntraperitoneal Injection129 SV MiceThree-Chamber ApparatusHabituationSocial InteractionBehavioral Parameters

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