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用于内皮靶向和药物传递的功能化10纳米高分子涂层金粒子的合成
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
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用于内皮靶向和药物传递的功能化10纳米高分子涂层金粒子的合成

DOI:
10.3791/56760-v

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10:38 min

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January 15, 2018

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, , , ,
1Department of Chemical Engineering,Northeastern University, 2Nanomedicine Science and Technology Center,Northeastern University, 3Department of Physics,Northeastern University, 4Departments of Bioengineering,Northeastern University, 5Department of Neuroscience,Albert Einstein College of Medicine

Chapters

  • 00:05Title
  • 00:38Synthesis of Polyethylene Glycol-coated Gold Nanoparticles (PEG-AuNPs)
  • 03:13Conjugation of Fluorophores onto the PEG-AuNP NH2 Groups
  • 04:56Characterization of Fluorescent PEG-AuNPs
  • 08:46Results: Size and Biocompatibility of THPC-coated and Fluorescent PEG-AuNPs
  • 10:19Conclusion

Summary

Automatic Translation

Automatic Translation

我们描述了一种合成具有生物相容性的10纳米金纳米粒子的方法, 其功能是在表面上涂上聚乙二醇。这些微粒可以使用在体外和在体内提供治疗的纳米细胞和细胞外空间, 难以获得常规纳米颗粒的大小。

Tags

Keywords: Gold NanoparticlesPolymer CoatingFunctionalizationEndothelium TargetingDrug DeliveryBiocompatibilityFluorescence ImagingTHPCChloroauric AcidPEGDialysisLyophilization

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