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A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts
 

A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts

Article DOI: 10.3791/57231-v 13:58 min September 10th, 2018
September 10th, 2018

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Summary

This method describes the placement of interposition vein grafts in rabbits, the transduction of the grafts, and the achievement of durable transgene expression. This allows the investigation of physiological and pathological roles of transgenes and their protein products in grafted veins, and testing of gene therapies for vein graft disease.

Tags

Keywords: Rabbit Model Transgene Expression Vein Graft Common Carotid Artery Graft Failure Vein Graft Endothelium Surgical Protocol Dissection Ligation Arteriotomy Vein Grafting
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