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由亲炎细胞因子的内脑注射诱导的广度脑皮质脱叶的鼠模型
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal Neuroscience
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
DOI:

09:46 min

September 21, 2021

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Chapters

  • 00:05Introduction
  • 01:15Catheter Implantation
  • 04:39Immunization
  • 05:57Intracerebral Cytokine Injection
  • 07:16Results: PLP Immunoreactivity in Coronal Brain Sections
  • 08:52Conclusion

Summary

Automatic Translation

这里提出的协议允许成年雄性黑阿古提大鼠的皮质半球广泛脱皮。该方法包括导管的内腔植入、骨髓寡细胞糖蛋白的亚临床免疫,以及通过植入导管对促炎细胞因子混合物的内腔注射。

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