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Syntese af 68Ga Core-doped jernoxid nanopartikler til dobbelt positronemissionstomografi / (T1) Magnetic Resonance Imaging
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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Syntese af 68Ga Core-doped jernoxid nanopartikler til dobbelt positronemissionstomografi / (T1) Magnetic Resonance Imaging

DOI:
10.3791/58269-v

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07:26 min

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November 20, 2018

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, , ,
1Nanobiotechnology, Molecular Imaging and Metabolomics Lab,Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 2CIC biomaGUNE and CIBER de Enfermedades Respiratorias (CIBERES). Ikerbasque, Basque Foundation for Science,Universidad Complutense de Madrid (UCM), 3Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC),CIBER de Enfermedades Respiratorias (CIBERES)

Chapters

  • 00:04Title
  • 00:26Synthesis of Citrate-Coated Iron Oxide Nanoparticles
  • 01:41Synthesis of 68Ga Core-Doped Iron Oxide Nanoparticles (68Ga-C-IONP)
  • 03:19Analysis of 68Ga Core-Doped Iron Oxide Nanoparticles (68Ga-C-IONP)
  • 04:42Results: Characterization of 68Ga Core-Doped Iron Oxide Nanoparticles
  • 06:40Conclusion

Summary

Automatic Translation

Automatic Translation

Vi præsenterer her, en protokol til at få68Ga core-doped jernoxid nanopartikler for via hurtigt mikrobølgeovn-drevet syntese. Metoden, der gengiver PET / (T1) Mr nanopartikler med radiolabeling effektivitetsgevinster højere end 90% og radiokemiske renhed på 99% i en 20-min syntese.

Tags

Keyword Extraction: 68GaCore-dopedIron Oxide NanoparticlesDual PET/MR ImagingMicrowave SynthesisReproducibleIron Chloride HexahydrateCitric Acid Trisodium Salt DihydrateHydrazine HydrateGel Filtration Desalting ColumnGallium-68 GeneratorGallium-68 ChlorideHydrodynamic Size

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