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En Hyperandrogenic musen Model til at studere polycystisk ovariesyndrom
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Developmental Biology
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JoVE Journal Developmental Biology
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

En Hyperandrogenic musen Model til at studere polycystisk ovariesyndrom

DOI:
10.3791/58379-v

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08:20 min

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October 02, 2018

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, , , , , ,
1Department of Pediatrics,Johns Hopkins University School of Medicine, 2Department of Health,Beijing Military General Hospital, 3Southern Medical University, 4Department of Molecular and Cellular Physiology,Johns Hopkins University School of Medicine, 5Department of Gynecology and Obstetrics,Johns Hopkins University School of Medicine

Chapters

  • 00:04Title
  • 00:47Dihydrotestosterone (DHT) Pellet Preparation
  • 02:04DHT Insertion and Replacement
  • 04:56Reproductive Profile Assessment of Female Offspring from Chronically DHT-inserted Dams
  • 06:27Results: Representative Mouse PCOS Model Analyses
  • 07:28Conclusion

Summary

Automatic Translation

Automatic Translation

Vi beskriver udviklingen af et lean PCOS-lignende musemodel med dihydrotestosteron pellet at studere Patofysiologi af PCOS og afkom fra disse PCOS-lignende dæmninger.

Tags

Keywords: Polycystic Ovary SyndromePCOSHyperandrogenismDihydrotestosteroneDHTMouse ModelSilicone TubingPellet ImplantationSurgical ProcedureAndrogen Exposure

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