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Journal / Immunology and Infection / Automated Behavioral Analysis of Large C. elegans …
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Immunology and Infection

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JoVE Journal Immunology and Infection
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
 

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

Article DOI: 10.3791/58643-v • 07:20 min • November 28th, 2018
November 28th, 2018 •
1, 1, 1, 2, 1, 1, 1
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen

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Summary
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We describe protocols for using the wide field-of-view nematode tracking platform (WF-NTP), which enables high-throughput phenotypic characterization of large populations of Caenorhabditis elegans. These protocols can be used to characterize subtle behavioral changes in mutant strains or in response to pharmacological treatment in a highly scalable fashion.

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Keywords: C. Elegans Automated Behavioral Analysis Drug Discovery Misfolding Diseases Aging Genetic Screenings Parallel Worm Tracker Image Capture Software
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