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提供纳米颗粒四种曝光浓度的单鼻子吸入毒性试验室的研制

JoVE Journal
Engineering

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JoVE Journal Engineering

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

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提供纳米颗粒四种曝光浓度的单鼻子吸入毒性试验室的研制

DOI:

10.3791/58725-v

•

05:07 min

•

March 18, 2019

•

Jae-Seong Yi², Ki-Soo Jeon, Hee-Jung Kim, Ki-Joon Jeon, Il-Je Yu

¹Department of Environmental Engineering,Inha University, ²HCTM Co. Ltd

Chapters

00:04Title
00:32Single-Concentration Exposure Chamber Testing with 0.1 wt% NaCl
01:50Multiconcentration Exposure Chamber Testing with 0.1 wt% NaCl
03:38Results: Flow and Particle Concentration Uniformity
04:32Conclusion

Summary

Automatic Translation

设计并验证了一个仅用于鼻吸入毒性的室, 该室能够检测四种不同接触浓度下的吸入毒性, 以确保每种浓度的接触端口之间的流场均匀性和交叉污染。在这里, 我们提出了一个协议, 以确认设计的室是有效的吸入毒性测试。

Tags

Nose-only Inhalation Toxicity Test Chamber Multi-concentration Exposure Nano-sized Particles OECD Guidelines Flow Velocity Particle Size Distribution Sodium Chloride Aerosol Air Flow Pressure Differential Humidity Control

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