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Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
 

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Article DOI: 10.3791/59024-v • 08:03 min • February 22nd, 2019
February 22nd, 2019 •
1,2, 2, 2, 2, 1,2
1Department of Medicine, University of Minnesota, 2Research Department, VA Health Care Center

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Summary
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We have developed an evoked measure of arthritis pain and coupled it with a standardized method for measuring spontaneous pain in different murine models of chemically induced arthritis. These measures are sensitive and reproducible for different types of joint pain.

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Keywords: Pain Measurement Arthritis Pre-clinical Models Evoked Pain Spontaneous Pain Knee Pain Anesthetized Mouse Joint Injection Algometry Vocalization Dynamic Weight Bearing
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