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Journal / Neuroscience / A High-content Assay for Monitoring AMPA Receptor …
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Neuroscience

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JoVE Journal Neuroscience
A High-content Assay for Monitoring AMPA Receptor Trafficking
 

A High-content Assay for Monitoring AMPA Receptor Trafficking

Article DOI: 10.3791/59048-v • 10:34 min • January 28th, 2019
January 28th, 2019 •
*1, *1, 1
1Neuroscience Institute, Georgia State University
* These authors contributed equally

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Summary
Automatic Translation

Neuronal excitability can be modulated through a dynamic process of endo- and exocytosis of excitatory ionotropic glutamate receptors. Described here is an accessible, high-content assay for quantifying surface and internal receptor population pools.

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Keywords: AMPA Receptor Trafficking High-content Assay Primary Neuronal Culture Surface And Intracellular Receptor Pools Receptor Trafficking Profiles Synaptic Loss Alzheimer's Disease TTX Treatment Anti-GluA1/GluA2 Antibody
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