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A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

DOI:
10.3791/60024-v

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00:07 min

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August 30, 2019

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, , ,
1Pulmonary and Critical Care Medicine, Department of Internal Medicine,Brigham and Women’s Hospital, Harvard Medical School

Chapters

  • 00:04Title
  • 00:53Hydrochloric Acid (HCL) Preparation
  • 01:39Surgical Preparation
  • 03:46Selective Intra-Bronchial HCL Instillation
  • 05:11Results
  • 06:38Conclusion

Summary

Automatic Translation

Automatic Translation

Selective intra-bronchial acid instillation to the left lung in mice results in unilateral and self-limited acute lung injury that models human acute respiratory distress syndrome (ARDS) induced by gastric acid aspiration.

Tags

Keywords: Acute Lung InjuryIntra-bronchial InstillationNonlethal ModelInflammatory ResponseHydrochloric AcidAnesthetized MouseTracheaSurgical Procedure

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