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A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury
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JoVE Journal Neuroscience
A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

DOI:
10.3791/60131-v

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07:36 min

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November 19, 2019

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, , , , , , , , , , ,
1Division of Neonatology, Department of Pediatrics,University of Washington, 2Department of Comparative Medicine,University of Washington

Chapters

  • 00:04Title
  • 00:44Surgical Preparation
  • 01:34Bilateral Carotid Artery Ligation
  • 02:44Sequential Hypoxia, Hyperoxia, and Hypoxia
  • 04:02Right Carotid Artery Ligation Reversal and Recovery and Temperature Management
  • 04:40Ex Vivo Brain Measurement
  • 05:33Results: Representative Morphological and Functional Injury Effects
  • 07:00Conclusion

Summary

Automatic Translation

Automatic Translation

The method describes inflammation-sensitized hypoxic-ischemic and hyperoxic brain injury in the P17 ferret to model the complex interaction between prolonged inflammation and oxidative brain injury experienced in a number of late preterm infants.

Tags

Keywords: Ferret ModelInflammation-sensitizedLate PretermHypoxic-ischemic Brain InjuryLPSCarotid Artery LigationHypoxiaHyperoxiaBrain Injury

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