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Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
 

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Article DOI: 10.3791/60351-v • 09:15 min • January 12th, 2020
January 12th, 2020 •
1,2, 3,4, 5,6, 6,7, 6,7
1Department of Pharmacology and Toxicology, University of Louisville, 2Hepatobiology and Toxicology Program, University of Louisville, 3Department of Physiology and Pharmacology, West Virginia University, 4Center for Inhalation Toxicology, West Virginia University, 5Department of Pharmacology and Chemical Biology, University of Pittsburgh, 6Pittsburgh Liver Research Center, University of Pittsburgh, 7Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh

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Summary
Automatic Translation

The goal of this protocol was to develop a murine model of low-level toxicant exposure that does not cause overt liver injury but rather exacerbates pre-existing liver damage. This paradigm better recapitulates human exposure and the subtle changes that occur upon exposure to toxicant concentrations that are considered safe.

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Keywords: Vinyl Chloride High-fat Diet Liver Damage Environment Obesity Inhalation Exposure Animal Model Chronic Exposure Safety Assessment Dietary Effects Environmental Factors Metabolic Health
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