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Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
DOI:

06:31 min

March 19, 2020

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Chapters

  • 00:04Introduction
  • 00:52Chloro-(n3-S,S,N)-[2,6-bis(N-isopropyl-N -methyleneimidazole-2-thione)pyridine]cobalt(II)tetrachlorocobaltate [4] Synthesis
  • 01:42Chloro-(n3-S,S,N)-[2,6-bis(N-isopropyl-N -methyleneimidazole-2-thione)pyridine]cobalt(II)tetrachlorocobaltate [4] Recrystallization
  • 02:34Chloro-(n3-S,S,N)-[2,6-bis(N-isopropyl-N -methylenetriazole-2-thione)pyridine]cobalt(II)tetrachlorocobaltate [5] Synthesis
  • 03:22Chloro-(n3-S,S,N)-[2,6-bis(N-isopropyl-N’-methylenetriazole-2-thione)pyridine]cobalt(II) tetrachlorocobaltate [5] Recrystallization
  • 04:28Results: Representative Liver Alcohol Dehydrogenase Complex Analyses
  • 05:41Conclusion

Summary

Automatic Translation

The preparation of SNS pincer cobalt(II) model complexes of liver alcohol dehydrogenase is presented here. The complexes can be prepared by reacting the ligand precursor with CoCl2·6H2O and can then be recrystallized by allowing diethyl ether to slowly diffuse into an acetonitrile solution that contains the cobalt complex.

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