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Immunology and Infection

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JoVE Journal Immunology and Infection
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
 
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In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Article DOI: 10.3791/61068-v • 09:19 min • May 24th, 2020
May 24th, 2020 •
1, 2,3, 4, 1, 3, 1, 1,5,6
1Department of Pulmonary Diseases, Amsterdam UMC, VU University Medical Center, Amsterdam Cardiovascular Sciences (ACS), 2BIOS Lab-on-a-Chip group, University of Twente, 3Applied Stem Cell Technologies Group, University of Twente, 4Department of Cardio-thoracic Surgery, Amsterdam UMC, VU University Medical Center, 5Institute of Physiology, Charité-Universitätsmedizin, 6German Heart Center

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We present an in vitro vascular disease model to investigate whole blood interactions with patient-derived endothelium. This system allows the study of thrombogenic properties of primary endothelial cells under various circumstances. The method is especially suited to evaluate in situ thrombogenicity and anticoagulation therapy during different phases of coagulation.

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Keywords: In Vitro Microfluidic Disease Model Whole Blood Endothelial Blood Clot Thrombogenicity Anticoagulant Inflammatory Personalized Medicine Pulmonary Artery Fibroronectin Endothelial Cell CD144 Flow Cytometry Flow Chamber Gelatin
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