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Exposition à la fumée de cigarette chez les souris utilisant un système d’inhalation du corps entier
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1Program in Immunology,Baylor College of Medicine, 2Department of Pediatrics, Section of Infectious Diseases,Baylor College of Medicine, 3Department of Medicine – Immunology Allergy and Rheumatology,Baylor College of Medicine, 4Department of Medicine, Pulmonary, Critical Care, Sleep Medicine,Baylor College of Medicine, 5Department of Pathology and Immunology,Baylor College of Medicine, 6Department of Pediatrics, Research and Department of Epigenetics and Molecular Carcinogenesis,The University of Texas MD Anderson Cancer Center, 7Division of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Sun Yat-sen University, 8Center for Translational Research on Inflammatory Diseases (CTRID),Michael E. DeBakey VA Medical Center
Chapters
- 00:04Introduction
- 00:34Setting Pressure and Airflow
- 01:46Cigarette Smoke Treatment
- 03:37Results: CS-mediated lnduction of Airway lnflammation and Lung Emphysematous Changes in Mice
- 05:14Conclusion
Ce protocole démontre l’étude des effets pathophysiologiques de la fumée de cigarette (CS) avec un système d’exposition de l’inhalation du corps entier (WBI) (WBIS) construit en interne. Ce système peut exposer les animaux au CS dans des conditions reproductibles contrôlées pour la recherche des effets médiés par le CS sur l’emphysème pulmonaire et l’hématopoïèse.
